Endoscopy and Biopsy • A transrectal needle biopsy is the removal of a small piece of the tumor for examination by a pathologist . Its accuracy can often be increased by guiding the needle with ultrasound . • Cystoscopy (passage of a small tube through the urinary canal) will provide a different view of the prostate and allow the doctor to move the prostate while it is being examined with a finger in the rectum. In this way, the lump can be felt from a variety of angles and it can be discovered whether the lump has become attached to adjacent tissues. • Flow cytometry and nuclear shape analysis are tests to evaluate the characteristics of the prostate cells removed by biopsy. Cancer cells are less uniform than normal ones.